Control of Venous Thromboembolism and Metastasis in Breast Cancer by Anti-Fibrinolysis Mechanism

Abstract

Formation of abnormal clots in vessels is a life-threatening situation and the second leading cause of death in cancer patients and is particularly common in breast cancer. Clot formation may also enhance tumor cells spread throughout the body. This study shows a tumor-related cell surface enzyme FAP as a potential contributor to abnormal clot formation and tumor cell survival and growth in blood mimics. Based on its results, new tests can be developed to identify breast cancer patients at high risk of developing abnormal clots. These patients can benefit most from preventive treatments. Also, agents specifically inhibiting the above enzyme have been investigated in this project to evaluate their use in preventing abnormal clot formation.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2010
Accession Number
ADA610996

Entities

People

  • Wen-tien Chen

Organizations

  • State University of New York

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Carcinoma
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Embolism And Thrombosis
  • Fibrin
  • Fibrin Modulating Agents
  • Fibrinolysis
  • Inhibitors
  • Neoplasms
  • Proteins
  • Survival
  • Tumor Cell Line

Fields of Study

  • Medicine

Readers

  • Molecular and Cellular Biochemistry
  • Oncology and Biomarker-Based Cancer Detection.
  • Trauma Surgery or Emergency Medicine.