Characterizing and Targeting Replication Stress Response Defects in Breast Cancer
Abstract
During the fourth year of this project, we have made significant progress in several of our proposed tasks. We found that TUSC4 is a potent tumor suppressor gene in breast cancer; its deficiency alone can sufficiently transform normal breast epithelial cells and promote tumor growth in mice. We further demonstrated that mechanistically TUSC4 protects BRCA1 protein from degradation by interfering its binding to Herc2 E3 ligase. In addition, we have validated the in vivo effects of MEK inhibitor, AZD6244 on targeting RSRD breast cancer cells in a xenograft mouse model. Finally, we have successfully optimized and reduced the size of hallow gold nanoparticle (HAuNS) and modified a functional group of AZD6244 so it can be conjugated to HAuNS.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2014
- Accession Number
- ADA611097
Entities
People
- Chun-jen Lin
- Hui Dai
- Ju-Seog Lee
- Lili Gong
- Shiaw-Yih Lin
Organizations
- The University of Texas MD Anderson Cancer Center