Protective Role of Ets1 in SLE

Abstract

Single nucleotide polymorphisms (SNP) at ets1 locus have been shown to increase the risk of SLE. Ets1-deficient mice display a few autoimmune features similar to SLE and their T cells produce an abnormally high level of IL-10 and a low level of IL-2, two features reminiscent of those of T cells of lupus patients. Ets1 directly binds to the il10 gene and recruited histone deacetylase, thereby suppressing the expression of IL-10. In contrast, Ets1 promotes IL-2 expression by an NFAT-dependent mechanism. We further found that the level of Ets1 in peripheral blood was negatively correlated with the level of anti-dsDNA. Our preliminary data suggest that Ets1 acts synergistically with Fc IIbR in counteracting the autoimmune process of SLE. Future direction is to investigate the molecular mechanism mediating the synergistic effect between Ets1 and Fc IIbR.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2014
Accession Number
ADA611429

Entities

People

  • I-cheng Ho

Organizations

  • Brigham and Women's Hospital

Tags

DTIC Thesaurus Topics

  • Blood
  • Cells
  • Chemistry
  • Genetics
  • Health Services
  • Lymphatic System
  • Lymphocytes
  • Medical Personnel
  • Proteins
  • Thymocytes

Fields of Study

  • Medicine

Readers

  • Molecular Biology and Genetics
  • Neurological Diseases/Conditions/Disorders