Extended Storage of Pathogen-Reduced Platelet Concentrates (PRECON)

Abstract

This grant pertains to increasing the availability and safety of platelets for transfusion. Ultimately our project proposes to determine the efficacy of using a pathogen inactivation technique (Mirasol) coupled with a Platelet Additive Solution (PAS) to extend the life of platelet concentrates. Preliminary steps to this ultimate goal are to determine the best storage bag and the optimum PAS to plasma ratio to utilize in our Mirasol experiments. Once we have established the optimum storage bag and PAS concentration we will evaluate the effects of Mirasol treatment on extended storage of PAS-stored platelet concentrates prepared from treated WB. These studies will be conducted using healthy donor autologous radiolabeled stored versus fresh platelet recovery and survival measurements to identify storage conditions that meet FDA post-storage platelet viability criteria. Thereafter, we will determine the post-transfusion recovery and survival of pre-storage pooled extended stored platelet concentrates prepared from Mirasol-treated WB given to thrombocytopenic patients.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2014
Accession Number
ADA611497

Entities

People

  • Sherrill J. Slichter

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Additives (Chemicals)
  • Biomedical Research
  • Blood
  • Blood Transfusions
  • Hemorrhage
  • Hemostasis
  • Inventions
  • Law
  • Maryland
  • Patents
  • Pathogenic Bacteria
  • Puget Sound
  • Recovery
  • Standards
  • Survival
  • Thrombocytopenia

Readers

  • Immunology
  • Materials Science
  • Trauma Surgery or Emergency Medicine.