Development of Modified Titanium Nitride Nanoparticles as Potential Contrast Material for Photoacoustic Imaging

Abstract

The focus of this project was to develop synthetic methodologies and evaluate Titanium Nitride (TiN)-based nanomaterials, as prospective contrast agents for Photoacoustic (PA) Tomography, according to the following program: 1. Development of methodologies for preparation of stable nano-suspensions of TiN nanoparticles (TiN NPs) in physiological solution and plasma, by using natural and synthetic dispersants. 2. Development of methodologies for preparation of TiN NPs nano-suspensions based on modification of TiN NPs by molecules capable of binding to TiN NPs and having biological receptor-targeting moieties. 3. Testing stability of the receptor-targeted TiN NPs nano-suspensions in physiological solution and in plasma. 4. Evaluation of cell-binding capabilities of the receptor-targeted TiN NPs vs. non-targeted TiN NPs in relevant cellular models.

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Document Details

Document Type
Technical Report
Publication Date
May 10, 2014
Accession Number
ADA611661

Entities

People

  • Michael Gozin

Organizations

  • Tel Aviv University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force Research Laboratories
  • Ball Mills
  • Blood
  • Carbon Nanotubes
  • Chemical Reactions
  • Chemical Synthesis
  • Chemistry
  • Materials
  • Measurement
  • Metallic Nanoparticles
  • Military Research
  • Nanomaterials
  • Nanoparticles
  • Particles
  • Photoacoustic Tomography
  • Polysaccharides
  • Tomography

Readers

  • Analytical Chemistry
  • Immunology
  • Nanoscale Plasmonic Nanotechnology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech