RNA Chimeras as a Gene Signature of Breast Cancer

Abstract

This project is set to test a hypothesis that breast cancer may express many RNA chimeras not only because there are fusion genes derived from chromosomal translocation or rearrangement but also because of abnormal trans-splicing of RNA transcripts. Many of these RNA chimeras may influence the behaviors of breast cancer via undiscovered mechanisms. One of the astonishing finding in 2012 fiscal year is the fusion RNAs formed between the nuclear RNA (nRNA) and mitochondrial RNA (mtRNA). Because such fusion, if it indeed exists in human cells, discloses a series of novel RNA processing mechanisms, in the past year we put much effort to analyze it and publish it. The major results from the work in the past year are summarized below.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2014
Accession Number
ADA612049

Entities

People

  • Dezhong Liao

Organizations

  • University of Minnesota

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cell Line
  • Cells
  • Chemical Reactions
  • Computers
  • Cytoplasm
  • Gene Expression
  • Genetics
  • Liquid Chromatography
  • Mass Spectrometry
  • Molecules
  • Neoplasms
  • Polymerase Chain Reaction
  • Proteins
  • Sequence Analysis
  • Spectra
  • United States

Fields of Study

  • Biology

Readers

  • Molecular Genetics
  • Molecular and genetic basis of cancer.
  • Theoretical Analysis.