Toxicity Evaluation of Engineered Nanomaterials: Portable In Vitro Chamber to Study Realistic Occupational Exposure in Biological Systems (Phase 2 Studies)
Abstract
The project entitled Toxicity Evaluation of Engineered Nanomaterials: Portable In Vitro Chamber to Study Realistic Occupational Exposure in Biological Systems focused on developing a fundamental understanding of the interaction of nanomaterials (NMs) with biological molecules and provides instrumentation and field methodology design to mimic realistic exposure scenarios to predict the toxicological effects of engineered NMs upon occupational human exposure. Although many studies are being conducted to investigate the toxicity of NMs, traditional techniques do not mimic realistic exposures, which can yield contradictory and inconclusive lab experimental results. This study describes the methodology necessary for mimicking realistic NM exposure, in addition to in situ NM characterization and toxicity kinetics and mechanisms. The final objective is to collect relevant toxicological data to support high accuracy predictive power for human risk assessment.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 12, 2012
- Accession Number
- ADA612260
Entities
People
- Carol Garrett
- Christin Grabinski
- Elizabeth Maurer
- Mohan Sankaran
- Nicole Schaeublin
- Ravindra Pandey :jerzy
- Saber Hussain
- William Trickler
Organizations
- Air Force Research Laboratory