The Influence of Primary Microenvironment on Prostate Cancer Osteoblastic Bone Lesion Development

Abstract

The loss of stromal TGF-(beta) signaling has been shown to initiate prostate cancer (PCa) and promote PCa progression. A further effect on osteoblastic bone lesion development was hypothesized and tested in this proposal. Using the Col(cre)/Tgfbr2 KO mice, we are able to knock out TGF-(beta) signaling specifically in the prostate fibroblasts and in bone osteoblasts. We found that PC3 cell osteolytic bone lesions were significantly increased in the KO mice tibiae compared to the flox mice tibia. bFGF was the only cytokine up-regulated (among many others down-regulated) in KO/PC3 tibiae relative to Flox/PC3 tibiae. However, osteoblastic bone lesions induced by LUCaP cells were inhibited in KO mice tibiae relative to Flox mice tibia in our preliminary study. Our findings suggest that osteoblastic TGF-(beta) signaling inhibits PCa osteolytic bone lesions but may promote PCa osteoblastic bone lesions.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2014
Accession Number
ADA612313

Entities

People

  • Xiaohong Li

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Bone And Bones
  • Cells
  • Cytokines
  • Fibroblasts
  • Growth Factors
  • Macrophages
  • Myeloid Cells
  • Neoplasms
  • Osteoblasts
  • Peptide Growth Factors
  • Peptides
  • Prostate
  • Prostate Cancer
  • Proteins
  • Tissues
  • X Rays

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology
  • Oncology (Cancer Research).
  • Prostate Cancer Biology.