RBC Storage Effect on Coagulation, Microparticles and Microchimerism in Critically Ill Patients

Abstract

The study aims include investigating specific mechanisms of adverse effects related to RBC storage age in critically ill patients. We continue to enroll patients in this study. Thus far, we have enrolled 82 patients, from whom samples have been collected, processed, shipped from Canada to San Francisco. We have completed coagulation testing on 90 patients samples and HLA typing for 54 patients Day 0 samples so far. Optimization work for the microparticle studies have built on related NIH-funded studies of in vitro properties of microparticles, refining the list of activation markers to be tested. We have completed microparticle testing for 6 patients.

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Document Details

Document Type
Technical Report
Publication Date
Jan 25, 2013
Accession Number
ADA612433

Entities

People

  • Avani Shah
  • Philip C Spinella
  • Phillip Norris

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Blood Coagulation Factor Inhibitors
  • Blood Coagulation Factors
  • Blood Transfusions
  • Chain Reactions
  • Chemical Reactions
  • Department Of Defense
  • Health Services
  • Hospitals
  • Inflammation
  • Information Operations
  • Microparticles
  • Optimization
  • Particles
  • Polymerase Chain Reaction
  • Protein C
  • Storage

Readers

  • Cardiovascular Physiology
  • Clinical Trial Research.