RBC Storage Effect on Coagulation, Microparticles and Microchimerism in Critically Ill Patients

Abstract

The study aim is to investigate specific mechanisms of adverse effects related to RBC storage age in critically ill patients. To date we have enrolled 130 patients at the three clinical sites in Canada. Samples have been collected, processed, and shipped from Canada to the repository at Blood Systems Research Institute (BSRI) in San Francisco, California. The repository consists of plasma, PBMCs and whole blood samples. The testing of patient samples for coagulation parameters, microparticles and microchimerism has begun. Results from these tests will be correlated with clinical outcomes and study groups upon study completion.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2014
Accession Number
ADA612434

Entities

People

  • Avani Shah
  • Philip C Spinella
  • Phillip J. Norris

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Blood Transfusions
  • Cardiovascular Diseases
  • Cytokines
  • Department Of Defense
  • Diseases And Disorders
  • Growth Factors
  • Health Services
  • Inflammation
  • Information Operations
  • Microparticles
  • Particles
  • Quality Control
  • Standards
  • Storage

Fields of Study

  • Medicine

Readers

  • Clinical Trial Research.
  • Immunology