Pathogen-Reduced, Plasmalyte-Extended Stored Platelets (PREPS)

Abstract

This grant pertains to finding novel approaches for storage of platelets for transfusion. Our project proposes to determine the efficacy of using a pathogen inactivation technique (Mirasol) coupled with a platelet storage solution (Plasmalyte) to extend the life of stored platelets. Our project also aims to determine how long acceptable platelet viability can be maintained in platelets derived from whole blood stored at 4 C. We have completed the regulatory activities necessary to initiate enrollment in the study of platelets in whole blood. We have developed the documents (IRB application, radiation safety application, consent etc.) for submission of the Mirasol/Plasmalyte portion of the study.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2013
Accession Number
ADA612437

Entities

People

  • Sherrill J. Slichter

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anticoagulants
  • Biomedical Research
  • Blood
  • Blood Donors
  • Cardiovascular Physiological Phenomena
  • Cellular Structures
  • Confidence Limits
  • Data Analysis
  • Department Of Defense
  • Diseases And Disorders
  • Health Services
  • Infectious Diseases
  • Institutional Review Board
  • Medical Personnel
  • Pain
  • Radiation
  • Side Effects

Readers

  • Clinical Trial Research.
  • Trauma Surgery or Emergency Medicine.