Research in Prevention and Treatment of Noise-Induced Hearing Loss (NIHL)

Abstract

The current study will identify D-methionine (D-met) dose and delayed time otoprotective response from steady state and impulse noise-induced hearing loss (NIHL). The second year was dedicated to determining the latest time D-met may be administered for efficient protection. Groups of Chinchillas laniger (n = 10) received five intraperitoneal D-met (200 mg/kg/dose) every 12 hours beginning 7, 9, 12, 18, 34, 36, or 48 hours after steady state or impulse. D-met otoprotection was assessed by auditory brainstem response (ABR) analysis and outer hair cell (OHC) quantification. ABR analyses identified time-dependent D-met protection from steady state and impulse noise exposures when D-met administration began as late as 24 hours post-noise exposure. Histological cytocochleogram analysis is still in progress to confirm electrophysiological assessment. Statistical analysis is currently in progress.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2014
Accession Number
ADA612546

Entities

People

  • Kathleen Campbell

Organizations

  • Southern Illinois University School of Medicine

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Research
  • Clinical Trials
  • Department Of Defense
  • Ear
  • Electronic Mail
  • Hearing Disorders
  • Hearing Loss
  • Impulse Noise
  • Information Operations
  • Medical Personnel
  • Methionine
  • Military Personnel
  • Noise
  • Protective Agents
  • Statistical Analysis
  • Steady State

Readers

  • Auditory Neuroscience/Auditory Physiology.
  • Systems Analysis and Design