Hibernation-Based Therapy to Improve Survival of Severe Blood Loss
Abstract
The purpose of these experiments was to address the dose response relationship for the toxicity of the drug product via I.V. or I.O. infusion and to assess the effectiveness of the drug to maintain adequate dosing concentrations when given either I.V. or I.O. We found no toxic effects from the drug when administered I.V. or I.O. as reported in pathology. Adequate dosing concentrations were maintained in animals receiving a high-dose of BHB/M. However, I.O. administration seemed to be more effective than the I.V. administration. When BHB/M was administered at full dose, I.V. administration was statistically more effective at maintaining the desired BHB/M concentrations when compared to the full dose BHB/M I.O. administration.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2012
- Accession Number
- ADA612549
Entities
People
- Greg Beilman
Organizations
- University of Minnesota