Microvesicle Production after Trauma and Its Clinical Impact on Venothromboembolism
Abstract
Polytrauma is most often caused from explosive devices and accounts for about 65 percent of injuries to our military personnel. The patients who have polytrauma are at increased risk of developing either bleeding and/or a clot in their veins which cause a life-threatening event known as venous thromboembolism (VTE). We began enrollment of patients into the study on 2 February 2011. As of 1 October 2014, we have successfully enrolled and collected blood samples on 1139 patients and 89 healthy volunteers. We have thus far analyzed plasma samples of over 443 patients and 89 volunteers. In our preliminary analysis of thrombin generation and procoagulant microvesicle analysis, we have observed that thrombin generation is accelerated early after traumatic injury and there are greater numbers of procoagulant microvesicles noted after traumatic injury relative to healthy volunteers.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2014
- Accession Number
- ADA612563
Entities
People
- Myung S. Park
Organizations
- Mayo Clinic