Prediction of Susceptibility to Acute Mountain Sickness Using Hypoxia-Induced Intrapulmonary Arteriovenous Shunt and Intracardiac Shunt Fractions
Abstract
We have spent the first year getting IRB approval and meeting with other experts in high altitude physiology and medicine to ensure that our research approach is solid. The following organizations have approved our protocol: a) Sacred Heart Medical Center IRB, the review board for Oregon Heart and Vascular Institute; b) Oregon Public Health and Safety (OPHS) and the University of Oregon Radiation Safety Committee; c) The State of Oregon; d) The University of Oregon IRB; e) The Department of Defense IRB. Robert Roach, Ph.D., Director of the Altitude Center at the University of Colorado School of Medicine provided us with an enormous amount of insight and assistance in ensuring that we will succeed in our aims. The hyperbaric chamber was set up and potential subjects have begun to be recruited. Two subjects have completed part of the protocol. The data thus far support our hypothesis that individuals who are susceptible to Acute Mountain Sickness (AMS) will have significantly greater amounts of shunt in hypoxia and/or have an intracardiac shunt such as a PFO and thus a greater degree of arterial hypoxemia than individuals who are not AMS susceptible.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2013
- Accession Number
- ADA612591
Entities
People
- Andrew T Lovering
Organizations
- University of Oregon