AltitudeOmics: The Basic Biology of Human Acclimatization to High Altitude
Abstract
After obtaining all necessary approvals, the data collection phase of this project was started and finished in 2012. We recruited and tested subjects at the University of Oregon, prepared the fieldwork sites in Bolivia, transported all equipment and all people successfully to Bolivia where we completed the protocol on 23 research subjects. Total data collected, including the physiology and OMICS data encompasses about 40 million data points. Since returning from Bolivia on September 15th we have been working non-stop on data analysis and manuscript preparation. The study was designed to yield a relatively quick turnaround for the core physiology studies, and a slightly slower but nonetheless fast turnaround for the OMICS analyses. As of January 15th, four months after completing the expedition, six of the physiology papers are drafted with the expectation of submission for publication by February 15th. On the OMICS side of the experiment, we did a two-step analysis process where data for gene expression, epigenetics and microRNA were analyzed for 10 subjects to a) verify that the samples we collected were viable and b) to identify the relative importance of various time points. That work was completed by late November. All samples tested to date were of very high quality, and significant signal existed at all major time points in the study suggesting that when the OMICS dataset is complete, we will have major new findings. Completion is expected in the next two weeks.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2013
- Accession Number
- ADA612593
Entities
People
- Robert Roach
Organizations
- University of Colorado Boulder