Targeting Androgen Receptor by Lysosomal Degradation in Prostate Cancer

Abstract

Androgen receptor (AR) plays a critical role in the progression of prostate cancer. This project is directed towards testing the feasibility of targeting AR for lysosomal degradation. We have demonstrated that AR can indeed be targeted for degradation by stimulating the TFEB lysosome degradation pathway either by increasing the TFEB levels or by activating TFEB using mTORC1 kinase inhibitor, torin 1. Additionally, we determined that the same approach can be used to target the EWS-Fli-1 oncoprotein for degradation.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2014
Accession Number
ADA612607

Entities

People

  • Yuzuru Shiio

Organizations

  • University of Texas Health Science Center at San Antonio

Tags

DTIC Thesaurus Topics

  • Androgen Receptors
  • Androgens
  • Biomedical And Dental Materials
  • Cells
  • Chemical Compounds
  • Chemistry
  • Inhibitors
  • Mass Spectrometry
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Proteins
  • Proteomics
  • Sarcoma
  • Spectrometry
  • Surface Plasmon Resonance
  • Transcription Factors

Fields of Study

  • Biology
  • Physics

Readers

  • Breast cancer cell signaling and growth regulation.
  • Prostate Cancer Biology.