Cavitation Induced Structural and Neural Damage in Live Brain Tissue Slices: Relevance to TBI

Abstract

Cavitation-induced shock wave, as might occur in the head during exposure to blast waves, was investigated as a possible damage mechanism for soft brain tissues. A novel experimental scheme was developed to visualize and control single bubble cavitation and its collapse, and the influence of this process on a nearby tissue surrogate was investigated. The experiment utilized a Hopkinson pressure bar system which transmits a simulated blast pressure wave (with over and under pressure components) to a fluid-filled test chamber implanted with a seed gas bubble.

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Document Details

Document Type
Technical Report
Publication Date
Sep 29, 2014
Accession Number
ADA612616

Entities

People

  • Ghatu Subhash

Organizations

  • University of Florida

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Blast Waves
  • Brain
  • Brain Injuries
  • Cerebral Cortex
  • Electron Microscopes
  • Electron Microscopy
  • Engineering
  • Materials
  • Materials Science
  • Measurement
  • Mechanical Properties
  • Mechanics
  • Medical Personnel
  • Neurosciences
  • Optical Properties
  • Statistical Analysis
  • Students

Fields of Study

  • Physics

Readers

  • Combustion Dynamics and Shock Wave Physics.
  • Neurotrauma and Rehabilitation Medicine.
  • Underwater engineering and Marine Technology.