Immobilization of Mitochondria on Graphene

Abstract

The research on mitochondria has been the focus of many scientists since the discovery of mitochondria DNA mutation as a cause of many health diseases and its major role in apoptosis. Various work has been done to measure the membrane potential of mitochondria which can inform scientists of the health state of the cells. The objective of this study was to learn more about mitochondria s surface properties and to consequently immobilize mitochondria on graphene. The surface of graphene was coated with Polyethyleneimine (PEI), Poly-L-Lysine (PLL), Lipid bilayer, and Polyethylene glycol (PEG) to study the immobilization of mitochondria on graphene. The technique used to remove unattached mitochondria as well as the staining method were both crucial factors in adhesion of mitochondria to the surface of grapheme.

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Document Details

Document Type
Technical Report
Publication Date
Aug 29, 2013
Accession Number
ADA612646

Entities

People

  • Elaheh Shekaramiz

Organizations

  • University of California, Irvine

Tags

Communities of Interest

  • Advanced Electronics

DTIC Thesaurus Topics

  • Alcohols
  • Biomedical And Dental Materials
  • Cell Membrane
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Coatings
  • Fatty Acids
  • Intracellular Membranes
  • Materials
  • Materials Processing
  • Materials Science
  • Membrane Lipids
  • Organic Chemistry
  • Polyethylene Glycols
  • Surface Plasmon Resonance

Readers

  • Molecular and Cellular Biochemistry
  • Nanoscale Plasmonic Nanotechnology

Technology Areas

  • Microelectronics
  • Microelectronics - Graphene