Trial of Naltrexone and Dextromethorphan for Gulf War Veterans' Illnesses

Abstract

This research study aims to expand the field of knowledge of Gulf War Illness. The research may provide initial proof of the innovative hypothesis that Gulf War Illness is related to low grade neuron-inflammation, which can be down regulated, by Naltrexone and Dextromethorphan. This is untested but potentially ground breaking concept that could provide, both an enhanced understanding of, and beneficial treatment for, Gulf War Illnesses. Research at the National Institute of Environmental Health and other facilities has proven that naltrexone and dextromethorphan reduce inflammation in the brain. Clinical trials in humans with low dose naltrexone have established benefits in syndromes related to Gulf War Illness such as fibromyalgia. We have successfully enrolled 41 subjects in the study, and anticipate obtaining important data by the end of the coming year. A no cost extension has been obtained to complete the study.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2014
Accession Number
ADA612826

Entities

People

  • William J. Meggs

Organizations

  • East Carolina University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Central Nervous System
  • Chemically-Induced Disorders
  • Clinical Trials
  • Data Analysis
  • Diseases And Disorders
  • Drug Abuse
  • Environmental Health
  • Inflammation
  • Mental Disorders
  • Nervous System
  • Peripheral Nervous System
  • Persian Gulf Syndrome
  • Side Effects
  • Substance-Related Disorders

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.