Simulation of Blast Loading on an Ultrastructurally-based Computational Model of the Ocular Lens
Abstract
Research progress over the past year focused on imaging of lens fiber cell structure using confocal laser scanning microscopy (CLSM), and type IV collagen structure using cryo-electron microscopy and tomography (cryo-EM and ET). The CLSM promises to generate good structural identification of lens fiber cells, while the cryo-EM and ET have not yet positively identified type IV collagen structure of the lens capsule. The collaboration with Dr. Vernerey of CU Boulder on large deformation Lagrangian-Eulerian computational modeling of the lens will be extended to three-dimensions (3D) and ultra-structurally based modeling of capsule and fiber cells. Such modeling could be extended to the whole eye globe, given the ease of using Eulerian-based methods in large deformation computational mechanics and solidfluid interaction. Tracking interfaces is the challenge, and such details are being investigated as part of the research.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2013
- Accession Number
- ADA612855
Entities
People
- Richard A Regueiro
Organizations
- University of Colorado Boulder