Abnormal Vestibulo-Ocular Reflexes in Autism: A Potential Endophenotype

Abstract

The overarching objective of this study was to characterize abnormalities of vestibulo-ocular reflexes in Autism Spectrum Disorder (ASD). Specific Aim 1: To characterize aberrations in horizontal VOR post-rotary nystagmus without optokinetic feedback using a velocity step test. We hypothesize that in ASD vertical eye movement intrusions during horizontal nystagmus will occur more frequently than normal, will be time-locked to horizontal nystagmus, and will differ from voluntary saccades. Specific Aim 2: To apply a linear systems analysis based method for testing horizontal VOR without optokinetic feedback using sinusoidal oscillation tests. We hypothesize that gain and phase lag of horizontal VOR will differ in children with ASD compared to controls. Specific Aim 3: To characterize in ASD vertical VOR and torsional VOR, both without optokinetic feedback, using velocity step tests.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2014
Accession Number
ADA612857

Entities

People

  • Keith D. White

Organizations

  • University of Florida

Tags

Communities of Interest

  • Air Platforms
  • Energy and Power Technologies

DTIC Thesaurus Topics

  • Autism
  • Brain
  • Cognitive Science
  • Databases
  • Health Services
  • Human Behavior
  • Intellectual Disability
  • Mental Disorders
  • Movement Disorders
  • Neurodevelopmental Disorders
  • Neurosciences
  • Psychiatry
  • Psychology
  • Test Methods

Fields of Study

  • Medicine

Readers

  • Brain and Cognitive Science; Experimental Psychology; Cognitive Neuroscience
  • Control Systems Engineering.
  • Molecular and genetic basis of cancer.