MMB-4 Inhibition of Aceylcholinesterase Is Similar across Species

Abstract

MMB-4, an oxime that can reactivate acetylcholinesterase (AChE) after inhibition by some nerve agents, is currently in advanced development for potential human use as a replacement for the currently fielded oxime 2-PAM. It has long been known that while certain oximes can be therapeutically effective against OP intoxication at appropriate doses, they can also act as reversible inhibitors of AChE at higher doses. This study was designed to test the hypothesis that the unexpected toxicity of MMB-4 in rabbits is due to increased sensitivity of rabbit AChE to inhibition by MMB-4 compared with AChE from other species.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2014
Accession Number
ADA612875

Entities

People

  • Douglas M. Cerasoli
  • Joshua Hofstetter A. Catherine
  • Karen Brecht
  • Michael V. Boeri
  • Shane A. Kasten

Organizations

  • United States Army Medical Research Institute of Chemical Defense

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acetylcholinesterases
  • Animals
  • Biomedical Research
  • Blood
  • Blood Cells
  • Cells
  • Data Acquisition
  • Department Of Defense
  • Dilution
  • Inhibition
  • Inhibitors
  • Lagomorphs
  • New Zealand
  • Reversible
  • Rodents
  • Sensitivity
  • Toxicity

Readers

  • Neurotoxicology