Hibernation-Based Therapy to Improve Survival of Severe Blood Loss

Abstract

The goal of this set of experiments was to determine whether a higher dose of BHB/M would improve outcomes. Based on the date presented, while animals treated with 2X 4 M BHB/43mM Melatonin did have death as well as other physiologic and hematologic changes associated with experimental outcome, animals treated with 4X 4 M BHB/43mM Melatonin had more severe outcomes and measures. Therefore, improved outcomes are not associated with a higher dose of BHB/M and in fact would appear detrimental. The individual components given I.V. to the injured animals at MTD (4X, determined in the previous set of experiments) resulted in death in 7/9 animals. Non-injured animals that received MTD (4X) of the individual components survived until the end of the experiments (8/8). It is concluded that it is likely that the animals died from a combination of both the injury and the high dosing of drug.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2014
Accession Number
ADA612890

Entities

People

  • Greg Beilman

Organizations

  • University of Minnesota

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biological Sciences
  • Biomedical Research
  • Blast Injuries
  • Blood
  • Blood Gases
  • Department Of Defense
  • Electronic Mail
  • Fluid Flow
  • Hemorrhagic Shock
  • Information Operations
  • Melatonin
  • Military Personnel
  • Resuscitation
  • Survival
  • Therapy
  • Torpor

Readers

  • Circadian Sleep-Wake Regulation and Chronobiology
  • Neurotrauma and Rehabilitation Medicine.
  • Toxicology/Environmental Toxicology