A New Therapeutic Paradigm for Breast Cancer Exploiting Low Dose Estrogen-Induced Apoptosis

Abstract

The purpose of gthe CoE is to discover the molecular mechanisms and the modulation estrogen-induced apoptosis. The laboratory research project is focused on genomics and proteomics with a current focus on molecular interrorgation to decipher mechanisms that may be applied to aid patient treatment. In parallel, but not supported by the CoE, is a pilot clinical study of estrogen-induced apoptosis in patients with metastatic breast cancer, that have had repeated cycles of successful antihormone therapy, but have subsequently failed and relapsed. A new low dos protocol is being completed. The molecular pharmacology

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2014
Accession Number
ADA613112

Entities

People

  • Virgil C. Jordan

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Medical Personnel
  • Organic Chemistry

Fields of Study

  • Biology
  • Medicine

Readers

  • Breast cancer cell signaling and growth regulation.
  • Clinical Trial Research.
  • Oncology and Biomarker-Based Cancer Detection.

Technology Areas

  • Biotechnology