Absorbable Antimicrobial Battlefield Hemostat

Abstract

The functional silicon nanofibers that can be effectively integrated into the resorbable dressing materials have been developed. Different substrates have been tested in our standard swine injury model. The gelatin sponge appears to be the promising material as a fully resorbable/biocompatible carrier matrix. The resorption of the nanofiber dressing has been demonstrated in situ. Afterwards, the effective surface functionalization strategies were developed that allow additional functionality to be attached to the nanofibers. The silicon nanofibers did not cause any major irritation or inflammatory response. The nanofibers can be manufactured at >100 g/day, and the integrating nanofibers into resorbable dressing materials can produce >200 bandages/day.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2012
Accession Number
ADA613168

Entities

People

  • Hugh Daniels
  • Jiao Chen
  • Julia Zhao
  • Min Wu
  • Nenny Fahruddin
  • Shaina Strating
  • Vamshi Chidara
  • Xiaodong Hou
  • Xu Wu
  • Yuanyu Zhao

Organizations

  • University of North Dakota

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anti-Infective Agents
  • Bandages
  • Battlefields
  • Cell Physiological Processes
  • Chemical Vapor Deposition
  • Coatings
  • Dip Coating
  • Electron Microscopes
  • Fibers
  • Materials
  • Microscopy
  • Nanofibers
  • North Dakota
  • Particles
  • Scanning Electron Microscopes
  • Standards
  • Substrates

Readers

  • Nanocomposite Materials Science
  • Trauma Surgery or Emergency Medicine.

Technology Areas

  • Biotechnology