Demyelination as a Target for Cell-Based Therapy of Chronic Blast-Induced Traumatic Brain Injury

Abstract

The burden of traumatic brain injury (TBI) is expressed in the disabling behavioral and cognitive abnormalities noted in significant number of combat veterans. These clinical phenotypes suggest impairment in distributed cerebral functions dependent on the integrity of white matter (WM) tracts. In this proposal we explore mechanisms of mild blast trauma-associated demyelination, with the goal of testing a therapeutic strategy to enhance remyelination using human glial restricted progenitors (hGRPs; Q Therapeutics Inc.).

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2014
Accession Number
ADA613176

Entities

People

  • Miroslaw Janowski

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Abnormalities
  • Acquisition
  • Apoptosis
  • Blast Injuries
  • Brain
  • Brain Injuries
  • Cell Physiological Processes
  • Data Acquisition
  • Department Of Defense
  • Diseases And Disorders
  • Image Processing
  • Medical Personnel
  • Overpressure
  • Professional Development
  • Stem Cells
  • Therapy
  • Training

Fields of Study

  • Medicine
  • Psychology

Readers

  • Immunology and Pathology
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.