Targeting Breast Cancer Stem Cells In Triple Negative Breast Cancer

Abstract

Obesity is associated with higher incidence of triple negative breast cancer (TNBC) and drug resistance. We hypothesize that obesity effects on TNBC occur via leptin-signaling stimulation of breast cancer stem cells (BCSC), which could involve the activation of VEGFR-2/Notch axis. During the first year of the funding period we performed in vitro studies in human TNBC cell lines treated with leptin, and novel leptin receptor inhibitor bound to nanoparticles (IONPs-LPrA) alone, and combined with cisplatin (a chemotherapeutic) and Sunitinib (an inhibitor of VEGFR-2 kinase). Our data show that leptin increased cell proliferation and expression of BCSC markers in human TNBC that was accompanied by induction of mammosphere formation, reduced effectiveness of cisplatin and sunitinib and increased expression and activation of Notch.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2014
Accession Number
ADA613188

Entities

People

  • Ruben R. Gonzalez-perez

Organizations

  • Morehouse School of Medicine

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Biomedical Research
  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Drug Resistance
  • Inhibition
  • Inhibitors
  • Intensity
  • Metal Oxide Nanoparticles
  • Nanoparticles
  • Neoplasms
  • Resistance
  • Stem Cells
  • Survival
  • Therapy

Fields of Study

  • Biology
  • Chemistry
  • Medicine

Readers

  • Molecular and Cellular Biology
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology