Psychosocial Stress and Ovarian Cancer Risk: Metabolomics and Perceived Stress

Abstract

Mouse models suggest that chronic stress promotes ovarian tumorigenesis, but the relationship between stress and ovarian cancer has never been evaluated in humans. In our analysis of self-reported stress and risk of ovarian cancer, we noted that phobic anxiety and social isolation were suggestively associated with increased risk of ovarian cancer (hazard ratios of 1.14 and 1.24, respectively). Depression was significantly associated with increased ovarian cancer risk (hazard ratio: 1.26), as was being widowed (hazard ratio: 1.38). Taken together, these data are consistent with animal data demonstrating the adverse impact of chronic stress on ovarian cancer risk.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2014
Accession Number
ADA613203

Entities

People

  • Elizabeth M Poole

Organizations

  • Brigham and Women's Hospital

Tags

DTIC Thesaurus Topics

  • Anxiety Disorders
  • Biomedical Research
  • Cancer
  • Department Of Defense
  • Depression
  • Diseases And Disorders
  • Gynecologic Cancers
  • Health
  • Health Services
  • Medical Personnel
  • Metabolomics
  • Neoplasms
  • Ovarian Cancer
  • Public Health
  • Social Psychology
  • Traumatic Stress Disorder

Fields of Study

  • Psychology

Readers

  • Aviation Safety Risk Assessment.
  • Molecular and genetic basis of cancer.
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.