Treating Combat Hearing Loss with Atoh1 Gene Therapy

Abstract

The goal of the project is to test experimental therapies for hearing loss in transgenic mouse models. We have developed molecular methods to identify sensory hair cells in the inner ear, including a validated genetic profile of sensory hair cells. We have generated and derived genetically modified mice to serve as models for treating hearing loss with gene therapy. We have shown that three such models are not suitable for our studies, but we have genetically engineered a fourth line and re-derived a fifth line from our collaborators. Finally, we have established and validated cell culture models to validate these mice and to investigate the molecular changes occurring in the ear following damage and treatment.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2011
Accession Number
ADA613205

Entities

People

  • Andrew K. Groves

Organizations

  • Baylor College of Medicine

Tags

DTIC Thesaurus Topics

  • Cell Physiological Processes
  • Cells
  • Diseases And Disorders
  • Ear
  • Gene Expression
  • Gene Therapy
  • Genetics
  • Hearing Disorders
  • Hearing Loss
  • Medical Personnel
  • Microarray Analysis
  • Organ Of Corti
  • Therapy
  • Transcription Factors

Fields of Study

  • Biology
  • Engineering

Readers

  • Auditory Neuroscience/Auditory Physiology.
  • Molecular and genetic basis of cancer.
  • Oncology

Technology Areas

  • Biotechnology