Biomarker of Exposure and Mechanism of Action of Toxic Industrial Chemicals (TICs)
Abstract
The twenty-first century warfighter will encounter the challenge of the potential use of toxic industrial chemicals (TICs) as chemical warfare agents. Large quantities of TICs are manufactured, stored, transported and used throughout the world. Many of these TICs are highly toxic and can rapidly affect exposed individuals causing severe injury and even deaths. Because TICs are stored and transported under relatively less secure conditions, these materials are easier for terrorists to inflict significant casualties against not only military but also civilian populations. In the event of a chemical attack, it will be vital to determine those individuals whose level of exposure would be anticipated to result in significant injury and possible death from those receiving only minimal or no exposure. The purpose of this project is to define the chemical signatures of the TICs acrylonitrile and acrolein in human blood, and potentially to devise a rapid, high throughput screening technology to enable examination of large groups of individuals following a known or suspected exposure. Studies have been directed toward defining the patterns of chemical reactivity of blood components with these TICs in order to use these adducts as biomarkers of chemical exposure. More recently experiments have focused on inventorying the tissue protein targets of acrylonitrile in order to gain insight into its mechanism of toxicity so that countermeasures (antidotes) may be developed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2013
- Accession Number
- ADA613259
Entities
People
- Donald E. Nerland
- Frderick W. Benz
- Harrell E. Hurst
- Jian Cai
Organizations
- University of Louisville