Optimizing Soft Tissue Management and Spacer Design in Segmental Bone Defects

Abstract

This proposal addresses the treatment of segmental bone defects and methods that can be used to manipulate the Masquelet induced membrane (IM) to create a graft bed that optimizes bone regeneration. The Chronic Caprine Tibial Defect (CCTD) model is used 1) to improve surgical technique and 2) to optimize spacer design; these are likely to advance bone regeneration strategies and translate into clinical practice.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2014
Accession Number
ADA613270

Entities

People

  • George F. Muschler

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Blood Coagulation
  • Bone And Bones
  • Bone Regeneration
  • Cartilage
  • Casualties
  • Cells
  • Chemistry
  • Connective Tissue
  • Gene Expression
  • Growth Factors
  • Military Medicine
  • Osteogenesis
  • Peptide Growth Factors
  • Proteins
  • Soft Tissues
  • Stem Cells
  • Tissues

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology
  • Nanocomposite Materials Science
  • Trauma or Military Medicine