Early Recognition of Chronic Traumatic Encephalopathy through FDDNP PET Imaging

Abstract

The PET biomarker, F-FDDNP (2-(l-{6-[(2-[F-lS]fluoroethyl(methyl)amino]-2-naphthyl} ethylidene) malononitrile) [FDDNP] has shown sensitivity for in vivo detection of tau in addition to I -sheet-containing brain amyloid neuroaggregates. Tau protein in a characteristic distribution is felt to be the cardinal pathologic feature of Chronic Traumatic Encephalopathy. This project will examine whether FDDNP PET imaging correlates with, and/or can predict, decline in cognitive function in those exposed to cumulative head trauma. All operational aspects of this study have been accomplished including local IRB approval, identification of potential subjects from the Profesional Fighters Brain Health Study to rec uit, logistics of the study visit and PET FDDNP imaging, case report forms, and electronic data entry. Actual enrollment of subjects has been delayed awaiting approval from tje Human Research Protection Office.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2014
Accession Number
ADA613274

Entities

People

  • Charles Bernick

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biological Markers
  • Biomedical Research
  • Blast Injuries
  • Brain Injuries
  • Chronic Encephalopathy
  • Department Of Defense
  • Detection
  • Head Injuries
  • Information Operations
  • Positron Emissions
  • Recognition
  • Sensitivity

Fields of Study

  • Medicine

Readers

  • Clinical Trial Research.
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.

Technology Areas

  • Microelectronics