Salivary Proteomic and microRNA Biomarkers Development for Lung Cancer Detection

Abstract

This is a lung cancer biomarker development project to test the hypothesis that there are discriminatory proteomic and miRNA biomarkers in saliva that can detect lung cancer with the aim to reduce the number unnecessary diagnostic workups (bronchoscopy) in patients with suspicious chest symptoms. Preliminary data is in place to support that our salivary biomarker technologies can discover and validate lung cancer biomarkers in saliva. The major goal is to perform a properly powered biomarker discovery and definitive validation of salivary proteomic and miRNA biomarkers for detection of lung cancer based on PRoBE design principles (prospective-specimencollection and retrospective-blinded-evaluation). The outcome of this three-year proposal will be a panel of definitively validated non-invasive saliva-based proteomic and micro-RNA biomarkers for detection of lung cancer.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2014
Accession Number
ADA613286

Entities

People

  • David Wong

Organizations

  • University of California, Los Angeles

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Biological Markers
  • Biomedical Research
  • Bronchoscopy
  • Cancer
  • Data Analysis
  • Data Sets
  • Demographic Cohorts
  • Department Of Defense
  • Detection
  • Emerging Technology
  • Health Services
  • Human Genome
  • Lung Cancer
  • Neoplasms
  • Standards
  • Test And Evaluation

Fields of Study

  • Medicine

Readers

  • Circadian Sleep-Wake Regulation and Chronobiology
  • Molecular and genetic basis of cancer.
  • Oncology

Technology Areas

  • Biotechnology