Molecular Characterization of Indolent Prostate Cancer
Abstract
Indolent prostate cancers that pose very low risk to aged men occur frequently and may be detected at biopsy, leading to the contemporary problem of prostate cancer over-diagnosis and over-treatment. The objective of the project is to define and characterize indolent prostate cancer using genomic approaches in the clinically relevant context of a cohort meeting the entry criteria for active surveillance. During this funding period, we have determined the optimal technical approaches to RNA sequencing in the specific setting of specimens derived from high-risk and low-risk prostate cancer, collaborated with urologists and pathologists involved in the active surveillance program to define a set of candidate genes to be examined in the active surveillance cohort, and conducted analysis of the longitudinal samples in the tissue repository suitable for the proposed studies. These progresses positioned us for studies designed to develop tools useful in guiding active surveillance.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2014
- Accession Number
- ADA613287
Entities
People
- Jun Luo
Organizations
- Johns Hopkins University