An Epigenetic Biomarker in PTSD

Abstract

There has been a growing recognition of the importance of epigenetic markers to PTSD. Epigenetic modifications are changes to the function (but not structure) of DNA that are caused by environmental exposures. To examine the extent to which an epigenetic marker cytosine methylation of the human glucocorticoid receptor as measured on the lymphocyte provides a relevant biomarker for PTSD. This will be accomplished by comparing cytosine methylation in combat veterans with and without PTSD. A second aim is to determine the association between cytosine methylation and the expression of glucocorticoid receptor related genes and splice variants of the human glucocorticoid receptor. Because we propose to measure cytosine methylation in the context of a large, multidisciplinary study (Biomarkers for PTSD: PI Dr. Charles Marmar NYUMC) we also propose to examine the relationship between this epigenetic measure and other well-studied correlates of PTSD.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2011
Accession Number
ADA613380

Entities

People

  • Rachel Yehuda

Organizations

  • Icahn School of Medicine at Mount Sinai

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biological Markers
  • Biomedical Research
  • Clinical Trials
  • Cytosine
  • Department Of Defense
  • Diseases And Disorders
  • Electronic Mail
  • Environmental Exposure
  • Governments
  • Information Operations
  • Methylation
  • Monitoring
  • National Governments
  • Recognition

Fields of Study

  • Biology

Readers

  • Mental Health of Military Veterans with Posttraumatic Stress Disorder (PTSD): Risk Factors, Prevalence, Symptoms, and Treatment.
  • Molecular Biology and Genetics
  • Molecular Genetics