Early Diagnosis and Intervention Strategies for Post-Traumatic Heterotopic Ossification in Severely Injured Extremities

Abstract

This study will recruit wounded warriors with severe extremity trauma, which places them at high risk for heterotopic ossification (HO); bone formation at abnormal sites, which causes pain, limits motion and/or limits the use of a prosthetic device. There are three goals: 1) to understand the mechanisms involved in HO; 2) to define accurate and practical methods to predict where HO will develop; and 3) to define potential therapies for prevention or mitigation of HO.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2014
Accession Number
ADA613386

Entities

People

  • George Muschler
  • Jonathan Forsberg
  • Tom Davis

Tags

DTIC Thesaurus Topics

  • Amputees
  • Blood
  • Casualties
  • Cells
  • Chemistry
  • Gene Expression
  • Growth Factors
  • Heterotopic Ossification
  • Military Medicine
  • Osteogenesis
  • Patient Care
  • Peptide Growth Factors
  • Peptides
  • Prosthetics
  • Proteins
  • Therapy
  • Transcription Factors

Fields of Study

  • Medicine

Readers

  • Aerial Delivery - Logistics and Supply Chain Management.
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.
  • Rehabilitation and Prosthetic Care for Military Service Members and Veterans with Limb Loss or Disability.