Broadly Applicable Nanowafer Drug Delivery System for Treating Eye Injuries
Abstract
Eye injuries require immediate and effective treatment to prevent corneal opacification, neovascularization, irregularity and occasionally ulceration of the cornea, which can be potentially blinding. Eye injuries are generally treated with eye drops for 4-8 times per day, which may not be feasible in critically injured patients in intensive care. This research project aims to develop a nanowafer drug delivery system that can deliver the drug to the eye for longer periods of time to treat eye injuries and prevent potential loss of vision. During the first year of this project, dexamethasone and doxycycline loaded nanowafers have been fabricated. The in vitro drug release kinetics from the nanowafers has been studied by HPLC analysis. The in vivo drug release in the mouse cornea by laser confocal fluorescence imaging study revealed that the nanowafers upon instillation on mouse eye were able to release the drug for up to 24 hours. We are presently optimizing the drug release for up to 5 days.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2014
- Accession Number
- ADA613401
Entities
People
- Stephen C. Pflugfelder Ghanashyam S.
Organizations
- Baylor College of Medicine