Ketone Body Metabolic Enzyme OXCT1 Regulates Prostate Cancer Chemoresistance

Abstract

Analysis of needle biopsy samples revealed that OXCT1 was upregulated in a subset of patients and the upregulation was associated with chemotherapy resistance. In vitro analysis showed that OXCT1 was overexpressed in various prostate cancer cell lines compared to benign prostate cells. OXCT1 stable knockdown cell lines in C42B, DU145 and PC3 were established. The optimal docetaxel doses and treatment time were determined. OXCT1 knockdown cells showed lower proliferation and higher sensitivity to docetaxel treatment. Cellular metablolic endpoints such as ATP and ROS were altered by ketone body supplementation. These results confirmed our hypothesis that OXCT1 plays important role prostate cancer chemotherapy sensitivity.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2014
Accession Number
ADA613410

Entities

People

  • Qiong Liu

Organizations

  • Oregon Health & Science University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Androgen Receptors
  • Biomedical Research
  • Cancer
  • Cell Line
  • Cells
  • Chemotherapy
  • Ketones
  • Metabolism
  • Neoplasms
  • Professional Development
  • Prostate
  • Prostate Cancer
  • Resistance
  • Sensitivity
  • Viability

Readers

  • Exercise and Sports Science.
  • Oncology (Cancer Research).
  • Oncology and Biomarker-Based Cancer Detection.