Pro-Lipogenic Action of Lysophosphatidic Acid in Ovarian Cancer
Abstract
The objective of the project is to determine the role of endogenous lysophosphatidic acid (LPA) in lipogenesis and metabolic abnormalities of ovarian cancer cells. During the second year of the funding support, the most significant advance we made was the identification of a previously unrecognized functional aspect of LPA-producing enzymes or LPA-synthesizing pathways such as iPLA2 and PLA2-autotaxin. They not only produce bioactive LPA but also regulate the availability of fatty acids for boxidation. We have obtained strong evidence that fatty acids and boxidation metabolism play an active role in driving cell proliferation and resistance to apoptosis. One of the key mediators of fatty acid b-oxidation is carnitine pamitoyl transferase 1A (CPT1A), which is overexpressed in malignant ovarian epithelial cells. Our results together indicate a dual role for lipid metabolism (LPA-driving lipogenesis and fatty acid catabolism) in support of malignant features of ovarian cancer cells. We have also obtained interesting results from other aspects of the project as detailed in the progress report. With the 6-month no extension that we have requested, we will be able to accomplish most of the project objectives.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2013
- Accession Number
- ADA613428
Entities
People
- Xianjun Fang
Organizations
- Virginia Commonwealth University