Neurocognitive and Biomarker Evaluation of Combination mTBI from Blast Overpressure and Traumatic Stress

Abstract

Mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) are major medical issues for the Warfighter. The current project is designed to evaluate the impact of mild traumatic brain injury (using blast overpressure) and the processes involved in traumatic stress (using a predator exposure procedure and a conditioned fear procedure) in a rodent model. The studies evaluate these insults alone and in combination to specifically address the question of whether mTBI can exacerbate the effects of psychological stress. Additionally, following the insults, a molecular biological evaluation is performed based upon the discovery of biomarkers that have been shown to be correlated with other forms of TBI. Thus, the project aims to systematically assess the combined effects of blast overpressure, traumatic stress and learned stress responses in rodents with the aim of understanding how these forces may interact to impact behavior as well as evaluating their outcome on known biomarkers involved in TBI and stress response system activation.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2014
Accession Number
ADA613444

Entities

People

  • Jitendra Dave
  • Raymond F. Genovese
  • Stephen Ahlers

Organizations

  • Geneva Foundation

Tags

DTIC Thesaurus Topics

  • Amnesia
  • Anxiety Disorders
  • Brain
  • Brain Injuries
  • Carrier Proteins
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemistry
  • Cytoskeleton
  • Depression
  • Mass Spectrometry
  • Mental Disorders
  • Neurosciences
  • Proteins
  • Proteomics
  • Traumatic Stress Disorder

Fields of Study

  • Psychology

Readers

  • Explosive Engineering.
  • Neuroscience
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.