Drug Delivery for Peripheral Nerve Regeneration

Abstract

Nerve injury can occur due to penetrating wounds, compression, traumatic stretch, and cold exposure. Despite prompt repair, outcomes are dismal. In this work, a polylacticcoglycolic acid (PLGA) nerve conduit with associated biodegradable drug reservoir is designed, fabricated, tested. Devices loaded with nerve growth factor (NGF) are evaluated for sustained drug release and axon growth enhancement in dorsal root ganglion (DRG) cells with the released drug. In the first year of this 18 month project we have completed device fabrication of the nerve guide conduit and drug delivery reservoir. Work is continuing to assess device efficacy and biocompatibility in Sprague dawley rat sciatic nerve model.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2014
Accession Number
ADA613477

Entities

People

  • Himanshu J. Sant
  • Jayant P. Agarwal

Organizations

  • University of Utah

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Data Analysis
  • Department Of Defense
  • Electron Microscopes
  • Engineering
  • Fabrication
  • Fluid Mechanics
  • Growth Factors
  • Inner Tubes
  • Lasers
  • Manufacturing
  • Mathematical Models
  • Medical Personnel
  • Peripheral Nervous System
  • Reservoirs
  • Sciatic Nerve
  • Students

Readers

  • Nanocomposite Materials Science
  • Neuroscience
  • Neurotrauma and Rehabilitation Medicine.