Noninvasive Detection and Differentiation of Axonal Injury/Loss, Demyelination, and Inflammation

Abstract

During year 2 of this funding support, we have developed more tools to demonstrate that DBSI is the future of diffusion MRI and neuroimaging modality to effectively detect underlying white matter tact pathologies noninvasively. We developed an objective quantitative histology analysis approach that allows an exact match between histology images and MRI maps. For situations where co-registered MRI-histology is not available due to data acquisition difficulties, the objective quantitative analysis of histology remains readily applicable. Current preliminary results suggest that DBSI detected axonal injury, demyelination, and inflammation closely correlated with histology findings. Most interestingly, results from the shorter time course of DBSI of optic nerve from EAE mice during acute ON indicated that visual impairment did not reflect underlying severity of optic nerve damage. DBSI detects all pathologies in optic nerves during ON.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2014
Accession Number
ADA613483

Entities

People

  • Anne H. Cross
  • Peng Sun
  • Sheng-kwei Song
  • William M. Spees
  • Yong Wang

Organizations

  • Washington University in St. Louis

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acquisition
  • Brain
  • Cells
  • Cellular Structures
  • Central Nervous System
  • Chemical Synthesis
  • Chemistry
  • Data Acquisition
  • Detection
  • Histology
  • Lymphocytes
  • Multiple Sclerosis
  • Nerve Tissue
  • Nervous System
  • Neural Pathways
  • Neuroglia
  • Neuroimaging

Fields of Study

  • Medicine

Readers

  • Medical Imaging.