Voxel-Wise Time-Series Analysis of Quantitative MRI in Relapsing-Remitting MS: Dynamic Imaging Metrics of Disease Activity Including Prelesional Changes

Abstract

Previous MRI studies in MS have retrospectively analyzed normal-appearing brain tissue in locations where typical MS lesions ultimately appeared, finding pre-lesional changes in several MRI metrics. However, studies have not been entirely consistent and the development of a prototypical MS lesion cannot as yet be prospectively predicted. The primary objective of this project is to validate the "preactive" lesion hypothesis in MS by identifying the spatiotemporal imaging signature of white matter destined to undergo acute, focal inflammation and demyelination-specifically, one that will allow reliable, prospective detection of nascent lesions before they appear on conventional (non-quantitative) imaging. The specific aim is to acquire a longitudinal set of quantitative MRI metrics in MS patients and perform a multivariate spatiotemporal analysis of pre-lesional, normal-appearing white matter, seeking spatially clustered interval changes that presage the appearance of a typical MS plaque.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2014
Accession Number
ADA613499

Entities

People

  • Aaron S. Field

Organizations

  • University of Wisconsin–Madison

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Accuracy
  • Biomedical Research
  • Department Of Defense
  • Detection
  • Diffusion
  • Electronic Mail
  • Image Processing
  • Inflammation
  • Information Operations
  • Intervals
  • Magnetic Resonance
  • Magnetic Resonance Imaging
  • Magnetization
  • Resonance
  • Statistical Analysis
  • Time Series Analysis

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