Effects of Acute Oral 5-aminotetrazole (5-AT) Exposure to Rats (Rattus norvegicus)
Abstract
5-AT is a potential replacement for perchlorate in pyrotechnic devices. The objectives of this study were to determine the oral acute and subacute toxicity of 5-AT in the rat. 5-AT was not acutely toxic and no mortalities were observed at the limit dose of 2000 milligrams per kilogram (mg/kg) body weight in the acute test. There were no clinical signs of toxicity or morbidity observed in the subacute 14-day study up to 623 mg/kg-day-- the highest dose tested for both male and female rats. Without adverse effects, determination of the LOAEL and derivation of the BMD were not possible. The NOAEL was 623 mg/kg-day, the highest dose used in the subacute exposure test. The acute and subacute tests indicated that 5-AT has low toxicity over a short expose time frame. 5-A Tis a less tox ic compound than perchlorate and it should be pursued as a replacement. Considering that 5-AT is also used in the synthesis of two other munition components, 5-nitrotetrazole (5-NT ) and copper (I) 5-nitrotetrazolate (DBX-1), a subchronic (90 day) oral study is recommended.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 12, 2015
- Accession Number
- ADA613520
Entities
People
- Valerie H. Adams
Organizations
- United States Army Public Health Command