Detection of Xenotropic Murine Leukemia Virus-Related Virus (XMRV) in Gulf War Illness: Role in Pathogenesis or Biomarker?

Abstract

The purpose of this project is to evaluate subjects with Gulf War illness (GWI) for pathogens and potential biomarkers. The scope of this work will primarily encompass transcriptional analysis of lymphocytes from individual with GWI and compare the results to the same data from healthy control volunteers. Any potential pathogens identified will be confirmed by complimentary methods. Additionally, we will also survey the production of inflammatory cytokines and chemokines from the same individuals as well as evaluate lymphocyte populations. This information will be used to produce a diagnostic signature that can be used to delineate those who suffer from GWI from those who do not. At this time, we are developing a potential diagnostic signature that can be used to distinguish GWI from healthy controls and a closely related illness, chronic fatigue syndrome (ME/CFS).

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2014
Accession Number
ADA613559

Entities

People

  • Vincent C. Lombardi

Organizations

  • Whittemore Peterson Institute

Tags

DTIC Thesaurus Topics

  • Cells
  • Chemistry
  • Health Services
  • Interferon
  • Lymphatic System
  • Lymphocytes
  • Medical Personnel
  • Persian Gulf Syndrome
  • Skin Diseases

Fields of Study

  • Medicine

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Molecular and genetic basis of cancer.
  • Systems Analysis and Design