Blast-Induced Acceleration in a Shock Tube: Distinguishing Primary and Tertiary Blast Injury
Abstract
With widespread use of improvised explosive devices and increased survivability due to advances in body armor, blast-induced TBI (bTBI) has emerged as a key military medical issue. In particular, the tremendous recent incidence of mild TBI in combat casualties has triggered several interrelated concerns, including establishment of means to improve mitigation and increase TBI resilience. These improvements are anticipated to hasten safe return-to-duty and minimize long-term and delayed TBI-related debilitations in returning veterans. This objective requires the utilization of high fidelity animal models to investigate the underlying neurobiological mechanisms of injury as a rational basis for establishing effective countermeasures. The etiology of bTBI is largely undefined, and several mechanisms, likely interactive, have been proposed. Using a well-validated blast model, we plan to focus on blast-induced acceleration of the head as one of the primary components of bTBI and establish the extent to which it contributes to the pathophysiology and functional impairments resulting from BOP exposure.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2014
- Accession Number
- ADA613618
Entities
People
- Joseph B. Long
Organizations
- Geneva Foundation