Corneal Protection for Burn Patients
Abstract
The overall goal of this research is to preserve vision of patients recovering from severe facial burns by providing an improved method to reduce development of corneal defects, inflammation, infection and opacification. Scope: To improve and understand the properties of the degradation-resistant crosslinked amniotic membranes for treating cornea of burn patients, Major findings: Identified three crosslinking methods that produced amnion with maximum protection against enzymatic degradation while remaining flexible enough to conform to cornea shape. Determined that protein crosslinking greatly reduces availability of beneficial factors in native amnion. Selected two crosslinking methods for in vivo evaluation. Demonstrated that with moderate crosslinking (chemical or photo crosslinking), one could improve with performance of the membrane (reduce degradation) without compromising its anti-inflammatory ability.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 2014
- Accession Number
- ADA613698
Entities
People
- Anthony J. Johnson
- Irene Kochevar
Organizations
- Henry M. Jackson Foundation for the Advancement of Military Medicine