Advanced MRI in Acute Military TBI

Abstract

The objective of the project is to test two advanced MRI methods, DTI and resting-state fMRI correlation analysis, in military TBI patients acutely after injury and correlate findings with TBI-related clinical outcomes 6-12 months later. The interaction of candidate genetic vulnerability factors with patterns of injury will be evaluated. These combined methods may add clinically useful predictive information following traumatic brain injury that could be of assistance in standardizing diagnostic criteria for TBI, making return-to-duty triage decisions, guiding post-injury rehabilitation, and developing novel therapeutics. The overarching hypothesis is that traumatic axonal injury, interacting with genetic vulnerability factors, is a principal cause of impaired brain function following blast-relate and non-blast-related TBI.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2014
Accession Number
ADA613778

Entities

People

  • David L. Brody

Organizations

  • Washington University in St. Louis

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amnesia
  • Brain Injuries
  • Health Services
  • Medical Personnel
  • Military Medicine
  • Neuroimaging
  • Patient Care
  • Surveys
  • Therapy
  • Traumatic Stress Disorder

Fields of Study

  • Medicine

Readers

  • Neurotrauma and Rehabilitation Medicine.
  • Team-Based Human-Centered Cognitive Task Decision Making and Information Performance.

Technology Areas

  • Biotechnology