Molecular Profiles for Lung Cancer Pathogenesis and Detection in U.S. Veterans
Abstract
During this DoD grant and program, we 1) understood how the molecular field of injury evolves spatiotemporally following curative surgery in NSCLC patients; 2) characterized the transcriptomic architecture of the adjacent airway field cancerization in NSCLC; 3) identified gradient profiles in the localized field cancerization that embody the nearby lung tumors; 4) demonstrated that the adjacent field cancerization extends to relatively less invasive large airways and harbors markers that can detect lung cancer in smokers; 5) validated the expression of a novel field cancerization marker, LAPTM4B, in airways and tumors in NSCLC patients; 6) revealed a novel interplay between LAPTM4B and the NRF2 transcription in mediating the NRF2-stress response and pathway for ensuing lung cancer cell growth and survival; 7) began to understand genomic aberrations (mutations and copy number alterations) in the airway field of cancerization and 8) mapped airway-wide molecular field of injury in NSCLC and pinpointing field profiles that inform of NSCLC pathogenesis and can detect lung cancer when assessed in minimally invasive sites in the lung. All in all, our data in this grant highlight the role of the field cancerization in lung cancer pathogenesis and the clinical opportunities for leveraging this phenomenon in lung cancer detection.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 18, 2014
- Accession Number
- ADA613782
Entities
People
- Humam Kadara
- Ignacio I. Wistuba
Organizations
- The University of Texas MD Anderson Cancer Center